News & Publications

SELECTED PUBLICATIONS

Following are selected peer-reviewed publications with General Metabolics founders and advisors.

Large Scale/Population Analyses

Chen, L., et al. Influence of the microbiome, diet and genetics on inter-individual variation in the human plasma metabolome.

Nature Medicine 2022, 28: 2333–2343.

Chen L, Wang D, Garmaeva S, et al. The long-term genetic stability and individual specificity of the human gut microbiome.

Cell. 2021;184(9):2302-2315.e12.

Temba, G.S., et al. Urban living in healthy Tanzanians is associated with an inflammatory status driven by dietary and metabolic changes.

Nature Immunology 2021, 22:287–300.

Cellular Mechanisms

Geiger, R. et al. L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity.

Cell 2016, 167: 829–842.

Xao, T., et al. Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism.

Nature 2017, 548(7666):228-233.

Disease and Related

Cherkaoui S, Durot S, Bradley J, et al. A functional analysis of 180 cancer cell lines reveals conserved intrinsic metabolic programs.

Mol Syst Biol. 2022;18(11):e11033.

Lingzi, L., et al. Metabolomics Identifies a Biomarker Revealing in Vivo Loss of Functional ß-Cell Mass Before Diabetes Onset.

Diabetes 2019, 68(12):2272-2286.  doi: 10.2337/db19-0131.

Kazak, L., et al. Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity.

 Cell Metabolism 2017, 26(4):660-671.

Mitroulis, I. et al. Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity.

Cell 2018, 172(1-2):147-161.

Presented Abstract, Rheos Medicines:  Camacho D., et al. Transcriptional Subsetting of SLE Patient Cohorts Based on Metabolic Pathway Activity [abstract].

Arthritis Rheumatol. 2021, 73 (suppl 9).

Fuhrer, T., et al. High-Throughput, Accurate Mass Metabolome Profiling of Cellular Extracts by Flow Injection time-of-Flight Mass Spectrometry.

 Analytical Chemistry 2011, 83(18):7074-80.

Integrated Omics and Metabolomics Methodology

Williams EG, Pfister N, Roy S, Statzer C, Haverty J, Ingels J, Bohl C, Hasan M, Čuklina J, Bühlmann P, Zamboni N, Lu L, Ewald CY, Williams RW, Aebersold R. Multiomic profiling of the liver across diets and age in a diverse mouse population.

 Cell Syst. 2022 Jan 19;13(1):43-57.e6. 

Holbrook-Smith, D. et al. High-throughput metabolomics predicts drug–target relationships for eukaryotic proteins.

Mol Systems Biology 2022, 18(2): e10767. 

Jha, A., et al. Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization.

Immunity 2015, 42(3): 419–430. doi: 10.1016/j.immuni.2015.02.005.

Sergushichev, A., et al. GAM: a web-service for integrated transcriptional and metabolic network analysis.

Nucleic Acids Research 2016, 44(W1): W194-200.

Microbiology & Microbiome Research

Blasche S, Kim Y, Mars RAT, Machado D, Maansson M, Kafkia E, Milanese A, Zeller G, Teusink B, Nielsen J, Benes V, Neves R, Sauer U, Patil KR. Metabolic cooperation and spatiotemporal niche partitioning in a kefir microbial community.

Nat Microbiol. 2021 Feb;6(2):196-208. doi: 10.1038/s41564-020-00816-5. Epub 2021 Jan 4. PMID: 33398099; PMCID: PMC7610452.

Zampieri, M., Hörl, M., Hotz, F. et al. Regulatory mechanisms underlying coordination of amino acid and glucose catabolism in Escherichia coli.

Nat Commun 10, 3354 (2019).

Diether M, Nikolaev Y, Allain FH, Sauer U. Systematic mapping of protein-metabolite interactions in central metabolism of Escherichia coli.

Mol Syst Biol. 2019 Aug;15(8):e9008. doi: 10.15252/msb.20199008. PMID: 31464375; PMCID: PMC6706640.
APPLICATION SPOTLIGHT

Following are summaries of recent publications by our clients and collaborators that highlight applications of our technology